Modified Citrus Pectin: Hype or helpful for cancer survivors? Why I take Modified Citrus Pectin as a breast cancer survivor
As a cancer coach and someone who has navigated my own breast cancer journey, I know how important it is to explore every avenue for supporting our healing—whether through conventional treatments, holistic approaches, or nutritional strategies. One such powerful and often-overlooked ally is Modified Citrus Pectin (MCP).
You may have heard about MCP from various sources or wondered if it could benefit you. As a cancer patient who’s undergone mastectomy, DIEP flap, and PAP flap surgeries for breast cancer reconstruction, I use MCP as part of my recovery process and want to share how it might support other cancer thrivers in the journey towards healing and reducing the risk of recurrence.
I was first introduced to MCP several years ago and then started to really learn about the science behind it during a presentation at the 2022 Annie Appleseed Project conference where the expert, Dr. Isaac Eliaz, MD, MS, LA.c showed us the very latest clinical studies in humans that helped me see how MCP can be of benefit to cancer patients along with use of other therapies all as guided by a licensed integrative practitioner who has been trained in the use of supplements like these.
Modified Citrus Pectin is a supplement derived from citrus fruit peels that’s been altered for better absorption by the body. In this blog, I’ll share the evidence-based benefits of MCP and why it might be worth considering for those of us navigating the complexities of cancer and recovery.
What is Modified Citrus Pectin?
Modified Citrus Pectin (MCP) is a type of pectin, a soluble fiber commonly found in citrus fruits. When modified, it’s broken down into smaller molecules, allowing it to be better absorbed by the body. While pectin is often used in making jams and jellies, this isn’t quite the same. So, you’ll need to get the modified supplement version for these cancer recovery purposes.
MCP has been shown to affect Galectin-3 (Gal-3) by binding to it and blocking its harmful effects. Galectin-3 is a type of protein found both inside and outside of cells. It plays a key role in various body processes, like helping cells stick together, move around, form new blood vessels, and even self-destruct when necessary. It’s mainly released by immune cells called macrophages and is involved in many important functions related to inflammation and disease.
MCP binds to Galectin-3, preventing it from attaching to cells and triggering harmful processes. This reduces inflammation, slows tumor growth, and helps prevent cancer from spreading (metastasis).
Why This Matters for Cancer Patients:
Galectin-3 is linked to cancer progression because it helps cancer cells stick together, grow, and spread. High levels of Gal-3 are also associated with chronic inflammation, fibrosis (scarring), and immune suppression—all of which can fuel cancer and other diseases. By blocking Gal-3, MCP may support the immune system, improve detoxification, and reduce the risk of metastasis.
MCP has powerful properties that have been studied for its potential health benefits, particularly for those living with cancer.
Evidence-Based Benefits of MCP for Cancer Patients:
- Supports Detoxification: MCP binds to heavy metals and toxins in the body, helping to safely remove them. As cancer patients, we often deal with the lingering effects of contrast IVs used in scans, treatments like chemotherapy, and other intense medications and therapies, making detox support crucial for restoring health.
- Inhibits Cancer Cell Metastasis: Studies suggest that MCP may help prevent cancer cells from spreading to other parts of the body by inhibiting the adhesion of cancer cells to the extracellular matrix, essentially making it harder for them to metastasize.
- Boosts Immune Function: MCP has been shown to help enhance the immune system by promoting the activity of immune cells, such as macrophages and natural killer cells, which are important for recognizing and destroying cancer cells.
- Promotes Healthy Inflammation Response: Cancer treatments like chemotherapy and radiation can lead to inflammation. MCP has natural anti-inflammatory properties, helping to reduce swelling and promote healing in the body.
- Supports Gut Health: Our gut is often a target during cancer treatments, with many patients experiencing digestive issues. MCP helps support a healthy gut microbiome, which is essential for immune function and overall health.
- Assists in Reducing Tumor Growth: Some research suggests that MCP can help slow the growth of certain types of tumors, making it a valuable adjunct therapy for cancer patients who are looking for ways to support their conventional treatment plan.
Citations
Ismail, Randa, et al., Modified citrus pectin ameliorates methotrexate-induced hepatic and pulmonary toxicity: role of Nrf2, galectin-3/TLR-4/NF-κB/TNF-α and TGF-β signaling pathways, Frontiers in Pharmacology, Volume 16, 2025, https://doi.org/https://doi.org/10.3389/fphar.2025.1528978.
Pratima Nangia-Makker, Victor Hogan, Yuichiro Honjo, Sara Baccarini, Larry Tait, Robert Bresalier, Avraham Raz, Inhibition of Human Cancer Cell Growth and Metastasis in Nude Mice by Oral Intake of Modified Citrus Pectin, JNCI: Journal of the National Cancer Institute, Volume 94, Issue 24, 18 December 2002, Pages 1854–1862, https://doi.org/10.1093/jnci/94.24.1854
Longjing Zhu, Stacie A. Chvatal, Heather B. Hayes, Daniel C. Millard, Cheryl T. Gomillion; Abstract 4918: Modified citrus pectin slows migration of triple negative breast cancer cells in an impedance-based scratch assay, Cancer Res 15 August 2020; 80 (16_Supplement): 4918. https://doi.org/10.1158/1538-7445.AM2020-4918
Keizman, D., Frenkel, M., Peer, A., Kushnir, I., Rosenbaum, E., Sarid, D., Leibovitch, I., Mano, R., Yossepowitch, O., Margel, D., Wolf, I., Geva, R., Dresler, H., Rouvinov, K., Rapoport, N., & Eliaz, I. (2021). Modified Citrus Pectin Treatment in Non-Metastatic Biochemically Relapsed Prostate Cancer: Results of a Prospective Phase II Study, Nutrients, 13(12), 4295. https://doi.org/10.3390/nu13124295
How I’ve Benefited from MCP in My Own Cancer Journey:
When I was recovering from my DIEP flap and PAP flap surgeries for breast cancer reconstruction, I looked for supplements that could help me in my recovery while also supporting my overall immune function. MCP has been one of the key additions to my regimen to support my post-surgery gut health and inflammation control. I also feel more supported in detoxing from the various IV and oral meds that were involved in my operations and ICU recoveries.
How I Take Modified Citrus Pectin:
MCP is usually available in powder or capsule form. The recommended dosage can vary, so it’s important to follow the instructions on the product you choose or consult with your healthcare provider. For many people, a daily dose of 5-15 grams is common, but always check with your doctor to ensure it’s right for you, especially if you’re undergoing active cancer treatment.
I prefer using the powder to create a drink in the mid-afternoon. I use the lemon-lime flavored one with purified water. I put a little still water in the bottom of the cup, then the scoop of powder, then mix it with a handheld frother. Once it is mixed (and don’t be surprised if it doesn’t fully absorb), I add some ice and top with sparkling water. This makes it seem like a fun little tasty drink.
If my practitioner recommend getting more than that serving a day, I would do a combo of the capsules and the powder. I’d do the capsules in the morning and evening (long before meals) and use the drink the in the afternoon.
The brand I use, which I have no affiliation with, is available at the functional medicine clinic I go to – so I buy it from my clinic. However, you can buy it online direct from the company here.
Conclusion:
Modified Citrus Pectin is a powerful, evidence-backed supplement that may offer numerous benefits for cancer patients, from supporting detoxification to reducing inflammation to inhibiting cancer cell metastasis. As someone who has walked the path of cancer, I consider MCP worth considering as part of a holistic approach to healing. As always, check with your doctor before adding new supplements to your routine to make sure they’re aligned with your treatment plan.
Bonus Tip:
Remember, healing from cancer involves a multifaceted approach. Alongside supplements like MCP, focusing on intentional anticancer nutrition, stress reduction, and emotional well-being is just as crucial as conventional therapies for fostering a strong recovery.
We can thrive, heal, and live with hope!
If you’re interested in exploring more ways to support your healing journey, reach out to me for personalized cancer coaching. Together, we can design a plan that nourishes your body, mind, and spirit.
